header

Publikationen

2016

Peer-review Originalarbeiten

Behrendt AK, Kuhla A, Osterberg A, Polley C, Herlyn P, Fischer DC, Scotland M, Wree A, Histing T, Menger MD, Müller-Hilke B, Mittlmeier T, Vollmar B. Dietary Restriction-Induced Alterations in Bone Phenotype: Effects of Lifelong Versus Short-Term Caloric Restriction on Femoral and Vertebral Bone in C57BL/6 Mice.  J Bone Miner Res 31:852-863, 2016

Puegge J, Wang Y, Roller J, Zhang S, Luo L, Vollmar B, Thorlacius H. Adhesive Mechanisms of Histone-Induced Neutrophil-Endothelium Interactions in the Muscle Microcirculation. Eur Surg Res 56:19-31, 2016

Dropmann A, Dediulia T, Breitkopf-Heinlein K, Korhonen H, Janicot M, Weber SN, Thomas M, Piiper A, Bertran E, Fabregat I, Abshagen K, Hess J, Angel P, Coulouarn C, Steven D, Meindl-Beinker NM. TGF-β1 and TGF-β2 abundance in liver diseases of mice and men. Oncotarget 7:19499-19518, 2016

Kuhla A, Derbenev M, Shih HY, Vollmar B. Prophylactic and abundant intake of α-lipoic acid causes hepatic steatosis and should be reconsidered in usage as an anti-aging drug. Biofactors 42:179-189, 2016

Oster M, Just F, Büsing K, Wolf P, Polley C, Vollmar B, Murani E, Ponsusksili S, Wimmers K. Towards improved phosphorus efficiency in monogastrics - Interplay of serum, minerals, bone and immune system after divergent dietary phosphorus supply in swine. Am J Physiol Regul Integr Comp Physiol 310:R917-R925, 2016

Eschler A, Roepenack P, Roesner J, Herlyn PK, Martin H, Reichel M, Rotter R, Vollmar B, Mittlmeier T, Gradl G. Cementless Titanium Mesh Fixation of Osteoporotic Burst Fractures of the Lumbar Spine Leads to Bony Healing: Results of an Experimental Sheep Model. Biomed Res Int 2016:4094161, 2016

Zechner D, Bürtin F, Albert AC, Zhang X, Kumstel S, Schönrogge M, Graffunder J, Shih HY, Müller S, Radecke T, Jaster R, Vollmar B. Intratumoral heterogeneity of the therapeutical response to gemcitabine and metformin. Oncotarget 2016 Jul 28. [Epub ahead of print]

Wichelhaus A, Beyersdoerfer ST, Vollmar B, Mittlmeier T, Gierer P. Four-Strand Core Suture Improves Flexor Tendon Repair Compared to Two-Strand Technique in a Rabbit Model. Biomed Res Int 2016:4063137, 2016

Bergt S, Gruenewald M, Beltschany C, Grub A, Neumann T, Albrecht M, Vollmar B, Zacharowski K, Roesner JP, Meybohm P. The fibrin-derived peptide Bβ15-42 (FX06) ameliorates vascular leakage and improves survival and neurocognitive recovery: Implications from two animal models of cardiopulmonary resuscitation. Crit Care Med 44:e988-995, 2016

Wichelhaus DA, Beyersdoerfer ST, Gierer P, Vollmar B, Mittlmeier T. The effect of a collagen-elastin matrix on adhesion formation after flexor tendon repair in a rabbit model. Arch Orthop Trauma Surg 136:1021-1029, 2016

Grambow E, Strüder D, Klar E, Hinz B, Vollmar B. Differential effects of endogenous, phyto and synthetic cannabinoids on thrombogenesis and platelet activity. Biofactors 2016 May 6 [Epub ahead of print]

Schmidt A, Bekeschus S, Wende K, Vollmar B, von Woedtke T. A cold plasma jet accelerates wound healing in a murine model of full-thickness skin wounds. Exp Dermatol 2016 Aug 5. [Epub ahead of print]

Zechner D, Kroemer T, Albert AC, Schönrogge M, Radecke T, Vollmar B. Analysis of Axin2 expression and function in murine models for pancreatic cancer. Cell Biosci 6:49, 2016

Wagner NM, Van Aken C, Butschkau A, Bierhansl L, Kellner P, Schleusener V, Seggewiss J, Vollmar B, Nöldge-Schomburg G, Roesner JP. Procalcitonin Impairs Endothelial Cell Function and Viability. Anesth Analg 2016 Sep 20. [Epub ahead of print]

Grambow E, Leppin C, Leppin K, Kundt G, Klar E, Frank M, Vollmar B. The effects of hydrogen sulfide on platelet-leukocyte aggregation and microvascular thrombolysis. Platelets 2016 Nov 7:1-9. [Epub ahead of print]

Rühlmann C, Wölk T, Blümel T, Stahn L, Vollmar B, Kuhla A. Long-term caloric restriction in ApoE-deficient mice results in neuroprotection via Fgf21-induced AMPK/mTOR pathway. Aging (Albany NY) 8:2777-2789, 2016

2015

Peer-review Originalarbeiten

Abshagen K, Brensel M, Genz B, Roth K, Thomas M, Fehring V, Schaeper U, Vollmar B. Foxf1 SiRNA delivery to hepatic stellate cells by DBTC lipoplex formulations ameliorates fibrosis in livers of bile duct ligated mice. Curr Gene Ther 15:215-227, 2015

Kuhla A, Thrum M, Schaeper U, Fehring V, Schulze-Topphoff U, Abshagen K, Vollmar B. Liver-specific Fas silencing prevents galactosamine/lipopolysaccharide-induced liver injury. Apoptosis 20:500-511, 2015

Behrendt AK, Beythien M, Huber J, Zufraß T, Butschkau A, Mittlmeier T, Vollmar B. New TiAg composite coating for bone prosthesis engineering shows promising microvascular compatibility in the murine dorsal skinfold chamber model. J Mater Sci Mater Med 26:5373, 2015

Kuhla A, Ludwig SC, Kuhla B, Münch G, Vollmar B. Advanced glycation end products are mitogenic signals and trigger cell cycle reentry of neurons in Alzheimer's disease brain. Neurobiol Aging 36:753-761, 2015

Pieper CC, Meyer C, Vollmar B, Hauenstein K, Schild HH, Wilhelm KE. Temporary arterial embolization of liver parenchyma with degradable starch microspheres (EmboCept®S) in a swine model. Cardiovasc Intervent Radiol 38:435-441, 2015

Laubert T, Freitag-Wolf S, Linnebacher M, König A, Vollmar B, Habermann JK; North German Tumorbank of Colorectal Cancer (ColoNet) consortium. Stage-specific frequency and prognostic significance of aneuploidy in patients with sporadic colorectal cancer-a meta-analysis and current overview. Int J Colorectal Dis 30:1015-1028, 2015

Zechner D, Radecke T, Amme J, Bürtin F, Albert AC, Partecke LI, Vollmar B. Impact of diabetes type II and chronic inflammation on pancreatic cancer. BMC Cancer 15:51, 2015

Sorg H, Hoffmann JO, Hoffmann JN, Vollmar B. Analysis of the influence of antithrombin on microvascular thrombosis: anti-inflammation is crucial for anticoagulation. Intensive Care Med Exp 3:58, 2015

Zechner D, Bürtin F, Amme J, Lindner T, Radecke T, Hadlich S, Kühn JP, Vollmar B. Characterization of novel carcinoma cell lines for the analysis of therapeutical strategies fighting pancreatic cancer. Cell Biosci 5:51, 2015

Eschler A, Roepenack P, Herlyn PK, Roesner J, Martin H, Vollmar B, Mittlmeier T, Gradl G. Intrabody application of eptotermin alpha enhances bone formation in osteoporotic fractures of the lumbar spine; however, fails to increase biomechanical stability - results of an experimental sheep model. Growth Factors 33:290-297, 2015

Abshagen K, Senne M, Genz B, Thomas M, Vollmar B. Differential Effects of Axin2 Deficiency on the Fibrogenic and Regenerative Response in Livers of Bile Duct-Ligated Mice. Eur Surg Res 55:328-340, 2015

Dold S, Richter S, Kollmar O, von Heesen M, Scheuer C, Laschke MW, Vollmar B, Schilling MK, Menger MD. Portal Hyperperfusion after Extended Hepatectomy Does Not Induce a Hepatic Arterial Buffer Response (HABR) but Impairs Mitochondrial Redox State and Hepatocellular Oxygenation. PLoS One 10:e0141877, 2015

Eschler A, Röpenack P, Herlyn PK, Roesner J, Pille K, Büsing K, Vollmar B, Mittlmeier T, Gradl G. The standardized creation of a lumbar spine vertebral compression fracture in a sheep osteoporosis model induced by ovariectomy, corticosteroid therapy and calcium/phosphorus/vitamin D-deficient diet. Injury 46:S17-23, 2015

Abshagen K, König M, Hoppe A, Müller I, Ebert M, Weng H, Holzhütter HG, Zanger UM, Bode J, Vollmar B, Thomas M, Dooley S. Pathobiochemical signatures of cholestatic liver disease in bile duct ligated mice. BMC Syst Biol 9:83, 2015

 

Übersichtsartikel, Buchbeiträge, Editorials, Briefe und Kommentare

Vogt P, Klar E, Roth P, Vollmar B. Editorial. Eur Surg Res 55:I, 2015

Abshagen K, Kuhla A, Genz B, Vollmar B. Anatomy and physiology of the hepatic circulation. Lanzer P (ed.) PanVascular Medicine, Springer-Verlag Berlin Heidelberg, 140:3607-3629, 2015

2014

Peer-review Originalarbeiten

Kern M, Kosacka J, Hesselbarth N, Brückner J, Heiker JT, Flehmig G, Klöting I, Kovacs P, Matz-Soja M, Gebhardt R, Krohn K, Sales S, Abshagen K, Shevchenko A, Stumvoll M, Blüher M, Klöting N. Liver-restricted Repin1 deficiency improves whole-body insulin sensitivity, alters lipid metabolism, and causes secondary changes in adipose tissue in mice. Diabetes 63:3295-3309, 2014

Butschkau A, Wagner NM, Genz B, Vollmar B. Protein Z exerts pro-angiogenic effects and upregulates CXCR4. PLoS One 9:e113554, 2014

Grambow E, Mueller-Graf F, Delyagina E, Frank M, Kuhla A, Vollmar B. Effect of the hydrogen sulfide donor GYY4137 on platelet activation and microvascular thrombus formation in mice. Platelets 25:166-174, 2014

Kuhla A, Hahn S, Butschkau A, Lange S, Wree A, Vollmar B. Lifelong caloric restriction reprograms hepatic fat metabolism in mice. J Gerontol A Biol Sci Med Sci 69:915-922, 2014

Zechner D, Spitzner M, Müller-Graff T, Vollmar B. Diabetes increases pancreatitis induced systemic inflammation but has little effect on inflammation and cell death in the lung. Int J Exp Pathol 95:411-417, 2014

Butschkau A, Wagner NM, Bierhansl L, Genz B, Vollmar B. Protein Z-deficiency is associated with enhanced neointima formation and inflammatory response after vascular injury in mice. Int J Clin Exp Pathol 7:6064-6071, 2014

Bigalke C, Luderer F, Wulf K, Storm T, Löbler M, Arbeiter D, Rau BM, Nizze H, Vollmar B, Schmitz KP, Klar E, Sternberg K. VEGF-releasing suture material for enhancement of vascularization: Development, in vitro and in vivo study. Acta Biomater 10:5081-5089, 2014

Meier C, Spitschak A, Abshagen K, Gupta S, Mor JM, Wolkenhauer O, Haier J, Vollmar B, Alla V, Pützer BM. Association of RHAMM with E2F1 promotes tumour cell extravasation by transcriptional up-regulation of fibronectin. J Pathol 234:351-364, 2014

Genz B, Thomas M, Pützer BM, Siatkowski M, Fuellen G, Vollmar B, Abshagen K. Adenoviral overexpression of Lhx2 attenuates cell viability but does not preserve the stem cell like phenotype of hepatic stellate cells. Exp Cell Res 328:429-443, 2014

Bannert K, Kuhla A, Abshagen K, Vollmar B. Anti-apoptotic therapeutic approaches in liver diseases: do they really make sense? Apoptosis 19:1243-1253, 2014

Donndorf P, Park H, Vollmar B, Alms A, Gierer P, Steinhoff G, Kaminski A. Impact of closed minimal extracorporeal circulation on microvascular tissue perfusion during surgical aortic valve replacement: intravital imaging in a prospective randomized study. Interact Cardiovasc Thorac Surg 19:211-217, 2014

Leppin K, Behrendt AK, Reichard M, Stachs O, Guthoff RF, Baltrusch S, Eule JC, Vollmar B. Diabetes mellitus leads to accumulation of dendritic cells and nerve fiber damage of the subbasal nerve plexus in the cornea. Invest Ophthalmol Vis Sci 55:3603-3615, 2014

Zechner D, Knapp N, Bobrowski A, Radecke T, Genz B, Vollmar B. Diabetes increases pancreatic fibrosis during chronic inflammation. Exp Biol Med (Maywood) 239:670-676, 2014

Worzfeld T, Swiercz JM, Sentürk A, Genz B, Korostylev A, Deng S, Xia J, Hoshino M, Epstein JA, Chan AM, Vollmar B, Acker-Palmer A, Kuner R, Offermanns S. Genetic dissection of plexin signaling in vivo. Proc Natl Acad Sci U S A 111:2194-2199, 2014

Knapik A, Kornmann K, Kerl K, Calcagni M, Schmidt CA, Vollmar B, Giovanoli P, Lindenblatt N. In vivo evaluation of wound bed reaction and graft performance after cold skin graft storage: new targets for skin tissue engineering. J Burn Care Res 35:e187-196, 2014

 

Übersichtsartikel, Buchbeiträge, Editorials, Briefe und Kommentare

Gianni-Barrera R, Bartolomeo M, Vollmar B, Djonov V, Banfi A. Split for the cure: VEGF, PDGF-BB and intussusception in therapeutic angiogenesis. Biochem Soc Trans 42:1637-1642, 2014

2013

Peer-review Originalarbeiten

Eipel C, Menschikow E, Sigal M, Kuhla A, Abshagen K, Vollmar B. Hepatoprotection in bile duct ligated mice mediated by darbepoetin-α is not caused by changes in hepatobiliary transporter expression. Int J Clin Exp Pathol 6:80-90, 2013

Gradl G, Herlyn P, Finke B, Gierer P, Wree A, Witt M, Mittlmeier T, Vollmar B. A pan-caspase inhibitor reduces myocyte apoptosis and neuropathic pain in rats with chronic constriction injury of the sciatic nerve. Anesth Analg 116:216-223, 2013

Kuhla A, Hauke M, Sempert K, Vollmar B, Zechner D. Senescence-dependent impact of anti-RAGE antibody on endotoxemic liver failure. Age (Dordr). 35:2153-2163, 2013

Oberländer M, Linnebacher M, König A, Bogoevska V, Brodersen C, Kaatz R, Krohn M, Hackmann M, Ingenerf J, Christoph J, Mate S, Prokosch HU, Yekebas EF, Thorns C, Büning J, Prall F, Uhlig R, Roblick UJ, Izbicki JR, Klar E, Bruch HP, Vollmar B, Habermann JK; On behalf of the ColoNet consortium. The "North German Tumor Bank of Colorectal Cancer": status report after the first 2 years of support by the German Cancer Aid Foundation. Langenbecks Arch Surg  398:251-258, 2013

Pasold J, Osterberg A, Peters K, Taipaleenmäki H, Säämänen AM, Vollmar B, Müller-Hilke B. Reduced expression of Sfrp1 during chondrogenesis and in articular chondrocytes correlates with osteoarthritis in STR/ort mice. Exp Cell Res 319:649-659, 2013

Stratos I, Li Z, Herlyn P, Rotter R, Behrendt AK, Mittlmeier T, Vollmar B. Vitamin D increases cellular turnover and functionally restores the skeletal muscle after crush injury in rats. Am J Pathol 182:895-904, 2013

Timm F, Vollmar B. Heterogeneity of the intrahepatic portal venous blood flow: Impact on hepatocyte transplantation. Microvasc Res 86:34-41, 2013

Kuehl AR, Abshagen K, Eipel C, Laschke MW, Menger MD, Laue M, Vollmar B. External inosculation as a feature of revascularization occurs after free transplantation of murine liver grafts. Am J Transplant 13:286-298, 2013

Donndorf P, Useini D, Lux CA, Vollmar B, Delyagina E, Laupheimer M, Kaminski A, Steinhoff G. Analysing migratory properties of human CD 133⁺ stem cells in vivo after intraoperative sternal bone marrow isolation. Cell Transplant 22:1627-1635, 2013

Knapik A, Kornmann K, Kerl K, Calcagni M, Contaldo C, Vollmar B, Giovanoli P, Lindenblatt N. Practice of split-thickness skin graft storage and histological assessment of tissue quality. J Plast Reconstr Aesthet Surg 66:827-834, 2013

Bobrowski A, Spitzner M, Bethge S, Mueller-Graf F, Vollmar B, Zechner D. Risk factors for pancreatic ductal adenocarcinoma specifically stimulate pancreatic duct glands in mice. Am J Pathol 182:965-974, 2013

Gierer P, Laue F, Hoffmann JN, Rotter R, Mittlmeier T, Gradl G, Vollmar B. Antithrombin reduces inflammation and microcirculatory perfusion failure in closed soft-tissue injury and endotoxemia. Crit Care Med 41:867-873, 2013

Maruschke M, Kram W, Nebe JB, Vollmar B, Zimpfer A, Hakenberg OW. Development of a rat model for investigation of experimental splinted uretero-ureterostomy, ureteral stenting and stenosis. In Vivo 27:245-249, 2013

Kram L, Grambow E, Mueller-Graf F, Sorg H, Vollmar B. The anti-thrombotic effect of hydrogen sulfide is partly mediated by an upregulation of nitric oxide synthases. Thromb Res 132:e112-117, 2013

Hergert B, Grambow E, Butschkau A, Vollmar B. Effects of systemic pretreatment with CpG oligodeoxynucleotides on skin wound healing in mice. Wound Repair Regen 21:723-729, 2013

Butschkau A, Nagel P, Grambow E, Zechner D, Broze GJ Jr, Vollmar B. Contribution of protein Z and protein Z-dependent protease inhibitor in generalized shwartzman reaction. Crit Care Med 41:e447-456, 2013

Engelmann D, Mayoli-Nüssle D, Mayrhofer C, Fürst K, Alla V, Stoll A, Spitschak A, Abshagen K, Vollmar B, Ran S, Pützer BM. E2F1 promotes angiogenesis through the VEGF-C/VEGFR-3 axis in a feedback loop for cooperative induction of PDGF-B. J Mol Cell Biol 5:391-403, 2013

Kuhla A, Lange S, Holzmann C, Maass F, Petersen J, Vollmar B, Wree A. Lifelong caloric restriction increases working memory in mice. PLoS One 8:e68778, 2013

Reetz J, Genz B, Meier C, Kowtharapu BS, Timm F, Vollmar B, Herchenröder O, Abshagen K, Pützer BM. Development of adenoviral delivery systems to target hepatic stellate cells in vivo. PLoS One 8:e67091, 2013

Kuhla A, Norden J, Abshagen K, Menger MD, Vollmar B. RAGE blockade and hepatic microcirculation in experimental endotoxaemic liver failure. Br J Surg 100:1229-1239, 2013

Wagner NM, Bierhansl L, Nöldge-Schomburg G, Vollmar B, Roesner JP. Toll-like receptor 2-blocking antibodies promote angiogenesis and induce ERK1/2 and AKT signaling via CXCR4 in endothelial cells. Arterioscler Thromb Vasc Biol 33:1943-1951, 2013

Zechner D, Sempert K, Genz B, Timm F, Bürtin F, Kroemer T, Butschkau A, Kuhla A, Vollmar B. Impact of hyperglycemia and acute pancreatitis on the receptor for advanced glycation endproducts. Int J Clin Exp Pathol 6:2021-2029, 2013

Bergt S, Wagner NM, Heidrich M, Butschkau A, Nöldge-Schomburg GE, Vollmar B, Roesner JP. Hydrocortisone reduces the beneficial effects of toll-like receptor 2 deficiency on survival in a mouse model of polymicrobial sepsis. Shock 40:414-419, 2013

Bergt S, Güter A, Grub A, Wagner NM, Beltschany C, Langner S, Wree A, Hildebrandt S, Nöldge-Schomburg G, Vollmar B, Roesner JP. Impact of toll-like receptor 2 deficiency on survival and neurological function after cardiac arrest: a murine model of cardiopulmonary resuscitation. PLoS One 8:e74944, 2013

Abshagen K, Mertens F, Eipel C, Vollmar B. Limited therapeutic efficacy of thrombopoietin on the regeneration of steatotic livers. Int J Clin Exp Pathol 6:1759-1769, 2013

Donndorf P, Ludwig M, Wildschütz F, Useini D, Kaminski A, Vollmar B, Steinhoff G. Intravital microscopy of the microcirculation in the mouse cremaster muscle for the analysis of peripheral stem cell migration. J Vis Exp 81:e50485, 2013

Wagner NM, Bierhansl L, Butschkau A, Noeldge-Schomburg G, Roesner JP, Vollmar B. TLR2-deficiency of cKit+ bone marrow cells is associated with augmented potency to stimulate angiogenic processes. Int J Clin Exp Pathol 6:2813-2823, 2013

 

Übersichtsartikel, Buchbeiträge, Editorials, Briefe und Kommentare

Vollmar B. Application of novel biomaterials in clinical surgery. Pathobiology 80:167-168, 2013

2012

Peer-review Originalarbeiten

Püschel A, Lindenblatt N, Katzfuß J, Vollmar B, Klar E. Immunosuppressants accelerate microvascular thrombus formation in vivo: Role of endothelial cell activation. Surgery 151:26-36, 2012

Eipel C, Hübschmann U, Abshagen K, Wagner KF, Menger MD, Vollmar B. Erythropoietin as additive of HTK preservation solution in cold ischemia/reperfusion injury of steatotic livers. J Surg Res 173:171-179, 2012

Stratos I, Richter N, Rotter R, Li Z, Zechner D, Mittlmeier T, Vollmar B. Melatonin restores muscle regeneration and enhances muscle function after crush injury in rats. J Pineal Res 52:62-70, 2012

Stratos I, Li Z, Rotter R, Herlyn P, Mittlmeier T, Vollmar B. Inhibition of caspase mediated apoptosis restores muscle function after crush injury in rat skeletal muscle. Apoptosis 17:269-277, 2012

Rezaeian F, Wettstein R, Scheuer C, Bäumker K, Bächle A, Vollmar B, Menger MD, Harder Y. Ghrelin protects musculocutaneous tissue from ischemic necrosis by improving microvascular perfusion. Am J Physiol Heart Circ Physiol 302:H603-610, 2012

Furlani D, Donndorf P, Westien I, Ugurlucan M, Pittermann E, Wang W, Li W, Vollmar B, Steinhoff G, Kaminski A, Ma N. HMGB-1 induces c-kit(+) cell microvascular rolling and adhesion via both toll-like receptor-2 and toll like receptor-4 of endothelial cells. J Cell Mol Med 16:1094-1105, 2012

Hirano K, Wagner K, Mark P, Pittermann E, Gäbel R, Furlani D, Li W, Vollmar B, Yamada T, Steinhoff G, Ma N. Erythropoietin attenuates the sequels of ischemic spinal cord injury with enhanced recruitment of CD34(+) cells in mice. J Cell Mol Med 16:1792-1802, 2012

Knapik A, Hegland N, Calcagni M, Althaus M, Vollmar B, Giovanoli P, Lindenblatt N. Metalloproteinases facilitate connection of wound bed vessels to pre-existing skin graft vasculature. Microvasc Res 84:16-23, 2012

Zechner D, Spitzner M, Bobrowski A, Knapp N, Kuhla A, Vollmar B. Diabetes aggravates acute pancreatitis and inhibits pancreas regeneration in mice. Diabetologia 55:1526-1534, 2012

Harms C, Helms K, Taschner T, Stratos I, Ignatius A, Gerber T, Lenz S, Rammelt S, Vollmar B, Mittlmeier T. Osteogenic capacity of nanocrystalline bone cement in a weight-bearing defect at the ovine tibial metaphysis. Int J Nanomedicine 7:2883-2889, 2012

Rotter R, Kraemer R, Stratos I, Vogt P, Vollmar B, Mittlmeier T, Knobloch K. Compartmental and muscular response to closed soft tissue injury in rats investigated by oxygen-to-see and intravital fluorescence microscopy. J Trauma Acute Care Surg 73:73-79, 2012

Donndorf P, Kühn F, Vollmar B, Rösner J, Liebold A, Gierer P, Steinhoff G, Kaminski A. Comparing microvascular alterations during minimal extracorporeal circulation and conventional cardiopulmonary bypass in coronary artery bypass graft surgery: A prospective, randomized study. J Thorac Cardiovasc Surg 144:677-683, 2012

Rotter R, Kuhn C, Stratos I, Beck M, Mittlmeier T, Vollmar B. Erythropoietin enhances the regeneration of traumatized tissue after combined muscle-nerve injury. J Trauma Acute Care Surg 72:1567-1575, 2012

Schiffmann L, Schwarz F, Linnebacher M, Prall F, Pahnke J, Krentz H, Vollmar B, Klar E. A novel sialyl LeX expression score as a potential prognostic tool in colorectal cancer. World J Surg Oncol 10:95, 2012

Behrendt AK, Meyer-Bahlburg A, Hansen G. CD137 deficiency does not affect development of airway inflammation or respiratory tolerance induction in murine models. Clin Exp Immunol 168:308-317, 2012

 

Übersichtsartikel, Buchbeiträge, Editorials, Briefe und Kommentare

Abshagen K, Eipel C, Vollmar B. A critical appraisal of the hemodynamic signal driving liver regeneration. Langenbecks Arch Surg 397:579-590, 2012

Vollmar B. Research as attractiveness parameter for young surgeons. Chirurg 83:319-322, 2012

Vollmar B. A new platform to become the forefront in the latest developments of experimental surgery. Eur Surg Res 48:1-2, 2012

Vollmar B, Roth P. Editorial. Eur Surg Res 49:I, 2012

2011

Peer-review Originalarbeiten

Eipel C, Hildebrandt A, Scholz B, Schyschka L, Minor T, Kreikemeyer B, Ibrahim SM, Vollmar B. Mutation of mitochondrial ATP8 gene improves hepatic energy status in a murine model of acute endotoxemic liver failure. Life Sci 88:343-349, 2011

Gock M, Eipel C, Linnebacher M, Klar E, Vollmar B. Impact of portal branch ligation on tissue regeneration, microcirculatory response and microarchitecture in portal blood-deprived and undeprived liver tissue. Microvasc Res 81:274-280, 2011

Xu W, Ganz C, Weber U, Adam M, Holzhüter G, Wolter D, Frerich B, Vollmar B, Gerber T. Evaluation of injectable silica-embedded nanohydroxyapatite bone substitute in a rat tibia defect model. Int J Nanomedicine 6:1543-1552, 2011

Kuhla A, Blei T, Jaster R, Vollmar B. Aging is associated with a shift of fatty metabolism toward lipogenesis. J Gerontol A Biol Sci Med Sci 66:1192-1200, 2011

Kuhla A, Trieglaff C, Vollmar B. Role of age and uncoupling protein-2 in oxidative stress, RAGE/AGE interaction and inflammatory liver injury. Exp Gerontol 46:868-876, 2011

Stratos I, Madry H, Rotter R, Weimer A, Graff J, Cucchiarini M, Mittlmeier T, Vollmar B. Fibroblast growth factor-2-overexpressing myoblasts encapsulated in alginate spheres increase proliferation, reduce apoptosis, induce adipogenesis, and enhance regeneration following skeletal muscle injury in rats. Tissue Eng Part A 17:2867-2877, 2011

Le Minh K, Berger A, Eipel C, Kuhla A, Minor T, Stegemann J, Vollmar B. Uncoupling protein-2 deficient mice are not protected against warm ischemia/reperfusion injury of the liver. J Surg Res 171:742-748, 2011

Harnoss JC, Heidecke CD, Vollmar B, Eipel C. In vivo imaging of bile accumulation and biliary infarction after common bile duct ligation in rats. Eur Surg Res 47:240-247, 2011

Siebert N, Xu W, Grambow E, Zechner D, Vollmar B. Erythropoietin improves skin wound healing and activates the TGF-β signaling pathway. Lab Invest 91:1753-1765, 2011

 

Übersichtsartikel, Buchbeiträge, Editorials, Briefe und Kommentare

Vollmar B, Menger MD. Intestinal ischemia/reperfusion: microcirculatory pathology and functional consequences. Langenbecks Arch Surg 396:13-29, 2011

Vollmar B. Pathophysiological basis of surgery-linked sepsis. Chirurg 82:199-207, 2011

Laschke MW, Vollmar B, Menger MD. The dorsal skinfold chamber: window into the dynamic interaction of biomaterials with their surrounding host tissue. Eur Cell Mater 22:147-167, 2011

Histing T, Garcia P, Holstein JH, Klein M, Matthys R, Nuetzi R, Steck R, Laschke MW, Wehner T, Bindl R, Recknagel S, Stuermer EK, Vollmar B, Wildemann B, Lienau J, Willie B, Peters A, Ignatius A, Pohlemann T, Claes L, Menger MD. Small animal bone healing models: Standards, tips, and pitfalls results of a consensus meeting. Bone 49:591-599, 2011

2010

Peer-review Originalarbeiten

Lindenblatt N, Platz U, Althaus M, Hegland N, Schmidt CA, Contaldo C, Vollmar B, Giovanoli P, Calcagni M. Temporary angiogenic transformation of the skin graft vasculature after reperfusion. Plast Reconstr Surg 126:61-70, 2010

Sigal M, Siebert N, Zechner D, Menschikow E, Abshagen K, Vollmar B, Eipel C. Darbepoetin-α inhibits the perpetuation of necro-inflammation and delays the progression of cholestatic fibrosis in mice. Lab Invest 90:1447-1456, 2010

Kollmar O, Corsten M, Scheuer C, Vollmar B, Schilling MK, Menger MD. Tumour growth following portal branch ligation in an experimental model of liver metastases. Br J Surg 97:917-926, 2010

Gierer P, Röther J, Mittlmeier T, Gradl G, Vollmar B. Ebselen reduces inflammation and microvascular perfusion failure after blunt skeletal muscle injury of the rat. J Trauma 68:853-858, 2010

Kuhla A, Hettwer C, Menger MD, Vollmar B. Oxidative stress-associated rise of hepatic protein glycation increases inflammatory liver injury in uncoupling protein-2 deficient mice. Lab Invest 90:1189-1198, 2010

Laschke MW, Schwender C, Vollmar B, Menger MD. Genistein does not affect vascularization and blood perfusion of endometriotic lesions and ovarian follicles in dorsal skinfold chambers of Syrian golden hamsters. Reprod Sci 17:568-577, 2010

Eipel C, Abshagen K, Ritter J, Cantré D, Menger MD, Vollmar B. Splenectomy improves survival by increasing arterial blood supply in a rat model of reduced-size liver. Transpl Int 23:998-1007, 2010

Traeger T, Mikulcak M, Eipel C, Abshagen K, Diedrich S, Heidecke CD, Maier S, Vollmar B. Kupffer cell depletion reduces hepatic inflammation and apoptosis but decreases survival in abdominal sepsis. Eur J Gastroenterol Hepatol 22:1039-1049, 2010

Tu-Rapp H, Pu L, Marques A, Kulisch C, Yu X, Gierer P, Ibrahim SM, Vollmar B. Genetic control of leucocyte-endothelial cell interaction in collagen-induced arthritis. Ann Rheum Dis 69:606-610, 2010

Yerebakan C, Klopsch C, Niefeldt S, Zeisig V, Vollmar B, Liebold A, Sandica E, Steinhoff G. Acute and chronic response of the right ventricle to surgically induced pressure and volume overload--an analysis of pressure-volume relations. Interact Cardiovasc Thorac Surg 10:519-525, 2010

Stratos I, Graff J, Rotter R, Mittlmeier T, Vollmar B. Open blunt crush injury of different severity determines nature and extent of local tissue regeneration and repair. J Orthop Res 28:950-957, 2010

Rezaeian F, Wettstein R, Egger JF, Sandmann F, Rücker M, Tobalem M, Vollmar B, Menger MD, Harder Y. Erythropoietin-induced upregulation of endothelial nitric oxide synthase but not vascular endothelial growth factor prevents musculocutaneous tissue from ischemic damage. Lab Invest 90:40-51, 2010

Gierer P, Scholz M, Beck M, Schaser KD, Vollmar B, Mittlmeier T, Gradl G. Microcirculatory sequelae of the rotator cuff after antegrade nailing in proximal humerus fracture. Arch Orthop Trauma Surg  130:687-691, 2010

Menzebach A, Bergt S, von Waldthausen P, Dinu C, Nöldge-Schomburg G, Vollmar B. A comprehensive study of survival, tissue damage, and neurological dysfunction in a murine model of cardiopulmonary resuscitation after potassium-induced cardiac arrest. Shock 33:189-196, 2010

 

Übersichtsartikel, Buchbeiträge, Editorials, Briefe und Kommentare

Vollmar B, Menger MD. Does experimental surgery still exist? Chirurg 81:323-327, 2010

Eipel C, Abshagen K, Vollmar B. Regulation of hepatic blood flow: the hepatic arterial buffer response revisited. World J Gastroenterol 16:6046-6057, 2010

Vollmar B, Eipel C, Menger MD. Therapeutic effects of erythropoietin in murine models of endotoxin shock. Crit Care Med 38:340-341, 2010

2009

Peer-review Originalarbeiten

Abshagen K, Schrodi I, Gerber T, Vollmar B. In vivo analysis of biocompatibility and vascularization of the synthetic bone grafting substitute NanoBone®. J Biomed Mater Res A 91:557-566, 2009

Le Minh K, Kuhla A, Abshagen K, Minor T, Stegemann J, Ibrahim S, Eipel C, Vollmar B. Uncoupling protein-2 deficiency provides protection in a murine model of endotoxemic acute liver failure. Crit Care Med 37:215-22, 2009

Rücker M, Laschke MW, Stamm A, Harder Y, Vollmar B, Menger MD. Local preconditioning by thermal stress accelerates microvascular thrombus formation. Shock 31:627-633, 2009

Kuhla A, Eipel C, Abshagen K, Siebert N, Menger MD, Vollmar B. Role of the perforin/granzyme cell death pathway in D-Gal/LPS-induced inflammatory liver injury. Am J Physiol Gastrointest Liver Physiol 296:G1069-1076, 2009

Furlani D, Ugurlucan M, Ong L, Bieback K, Pittermann E, Westien I, Wang W, Yerebakan C, Li W, Gaebel R, Li RK, Vollmar B, Ma N, Steinhoff G. Is the intravascular administration of mesenchymal stem cells safe? Microvasc Res 77:370-376, 2009

Roesner JP, Petzelbauer P, Koch A, Tran N, Iber T, Vagts DA, Scheeren TW, Vollmar B, Nöldge-Schomburg GE, Zacharowski K. Bbeta15-42 (FX06) reduces pulmonary, myocardial, liver, and small intestine damage in a pig model of hemorrhagic shock and reperfusion. Crit Care Med 37:598-605, 2009

Roesner JP, Petzelbauer P, Koch A, Tran N, Iber T, Mutz C, Vollmar B, Nöldge-Schomburg GE, Zacharowski K. A double blind, single centre, sub-chronic reperfusion trial evaluating FX06 following haemorrhagic shock in pigs. Resuscitation 80:264-271, 2009

Sorg H, Krueger C, Schulz T, Menger MD, Schmitz F, Vollmar B. Effects of erythropoietin in skin wound healing are dose related. FASEB J 23:3049-3058, 2009

Eipel C, von Hardenberg J, Negendank S, Abshagen K, Vollmar B. Thrombopoietin limits IL-6 release but fails to attenuate liver injury in two hepatic stress models. Eur J Gastroenterol Hepatol 21:923-931, 2009

Erős G, Ibrahim S, Siebert N, Boros M, Vollmar B. Oral phosphatidylcholine pretreatment alleviates the signs of experimental rheumatoid arthritis. Arthritis Res Ther 11:R43, 2009

Harder Y, Amon M, Schramm R, Contaldo C, Metzkow E, Matzen A, Rücker M, Vollmar B, Menger MD. Erythropoietin reduces necrosis in critically ischemic myocutaneous tissue by protecting nutritive perfusion in a dose-dependent manner. Surgery 145:372-383, 2009

Yerebakan C, Klopsch C, Prietz S, Boltze J, Vollmar B, Liebold A, Steinhoff G, Sandica E. Pressure-volume loops: feasible for the evaluation of right ventricular function in an experimental model of acute pulmonary regurgitation? Interact Cardiovasc Thorac Surg 9:163-168, 2009

Wiessner R, Gierer P, Schaser K, Pertschy A, Vollmar B, Klar E. Microcirculatory failure of sublingual perfusion in septic-shock patients. Examination by OPS imaging and PiCCO monitoring. Zentralbl Chir 134:231-236, 2009

Yerebakan C, Sandica E, Prietz S, Klopsch C, Ugurlucan M, Kaminski A, Abdija S, Lorenzen B, Blotze J, Nitzsche B, Egger D, Barten M, Furlani D, Ma N, Vollmar B, Liebold A, Steinhoff G. Autologous umbilical cord blood mononuclear cell transplantation preserves right ventricular function in a novel model of chronic right ventricular volume overload. Cell Transplant 18:855-868, 2009

Xu W, Holzhüter G, Sorg H, Wolter D, Lenz S, Gerber T, Vollmar B. Early matrix change of a nanostructured bone grafting substitute in the rat. J Biomed Mater Res B Appl Biomater 91:692-699, 2009

Sorg H, Schulz T, Krueger C, Vollmar B. Consequences of surgical stress on the kinetics of skin wound healing: partial hepatectomy delays and functionally alters dermal repair. Wound Repair Regen 17:367-377, 2009

 

Übersichtsartikel, Buchbeiträge, Editorials, Briefe und Kommentare

Ritz JP, Gröne J, Hopt U, Saeger HD, Siewert JR, Vollmar B, Lauscher JC, Lehmann KS, Buhr HJ. Practical course for visceral surgery in Warnemünde" 10 years on. Significance and benefits of a surgical training course. Chirurg 80:864-871, 2009

Laschke MW, Vollmar B, Menger MD. Inosculation: connecting the life-sustaining pipelines. Tissue Eng Part B Rev 15:455-465, 2009

Vollmar B, Menger MD. The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair. Physiol Rev 89:1269-1339, 2009

2008

Peer-review Originalarbeiten

Abshagen K, Eipel C, Kalff JC, Menger MD, Vollmar B. Kupffer cells are mandatory for adequate liver regeneration by mediating hyperperfusion via modulation of vasoactive proteins. Microcirculation15:37-47, 2008

Cantré D, Schuett H, Hildebrandt A, Dold S, Menger MD, Vollmar B, Eipel C. Nitric oxide reduces organ injury and enhances regeneration of reduced-size livers by increasing hepatic arterial flow. Br J Surg 95:785-792, 2008

Gierer P, Hoffmann JN, Mahr F, Menger MD, Mittlmeier T, Gradl G, Vollmar B. Sublethal trauma model with systemic endotoxemia for the study of microcirculatory disorders after the second hit. J Surg Res 147:68-74, 2008

Harder Y, Amon M, Laschke MW, Schramm R, Rücker M, Wettstein R, Bastiaanse J, Frick A, Machens HG, Küntscher M, Germann G, Vollmar B, Erni D, Menger MD. An old dream revitalised: preconditioning strategies to protect surgical flaps from critical ischaemia and ischaemia-reperfusion injury. J Plast Reconstr Aesthet Surg 61:503-511, 2008

Hoffman JN, Fertmann JM, Vollmar B, Laschke MW, Jauch KW, Menger MD. Immunoglobulin M-enriched human intravenous immunoglobulins reduce leukocyte-endothelial cell interactions and attenuate microvascular perfusion failure in normotensive endotoxemia. Shock 29:133-139, 2008

Jaeger K, Selent C, Jaehme W, Mahr S, Goebel U, Ibrahim S, Vollmar B, Mueller-Hilke B. The genetics of osteoarthritis in STR/ort mice. Osteoarthritis Cartilage Osteoarthritis Cartilage 16:607-614, 2008

Kaminski A, Ma N, Donndorf P, Lindenblatt N, Feldmeier G, Ong LL, Furlani D, Skrabal CA, Liebold A, Vollmar B, Steinhoff G. Endothelial NOS is required for SDF-1alpha/CXCR4-mediated peripheral endothelial adhesion of c-kit+ bone marrow stem cells. Lab Invest 88:58-69, 2008

Klemm K, Eipel C, Cantré D, Abshagen K, Menger MD, Vollmar B. Multiple doses of erythropoietin impair liver regeneration by increasing TNF-alpha, the Bax to Bcl-xL ratio and apoptotic cell death. PLoS ONE 3:e3924, 2008

Kuhla A, Eipel C, Siebert N, Abshagen K, Menger MD, Vollmar B. Hepatocellular apoptosis is mediated by TNFalpha-dependent Fas/FasLigand cytotoxicity in a murine model of acute liver failure. Apoptosis 13:1427-1438, 2008

Laschke MW, Schwender C, Scheuer C, Vollmar B, Menger MD. Epigallocatechin-3-gallate inhibits estrogen-induced activation of endometrial cells in vitro and causes regression of endometriotic lesions in vivo. Hum Reprod 23:2308-2318, 2008

Lindenblatt N, Calcagni M, Contaldo C, Menger MD, Giovanoli P, Vollmar B. A new model for studying the revascularization of skin grafts in vivo: the role of angiogenesis. Plast Reconstr Surg 122:1669-1680, 2008

Olschewski P, Hunold G, Eipel C, Neumann U, Schöning W, Schmitz V, Vollmar B, Neuhaus P, Puhl G. Improved microcirculation by low-viscosity histidine- tryptophan-ketoglutarate graft flush and subsequent cold storage in University of Wisconsin solution: results of an orthotopic rat liver transplantation model. Transpl Int 21:1175-1180, 2008

Rotter R, Menshykova M, Winkler T, Matziolis G, Stratos I, Schoen M, Bittorf T, Mittlmeier T, Vollmar B. Erythropoietin improves functional and histological recovery of traumatized skeletal muscle tissue. J Orthop Res 26:1618-1626, 2008

Schoen M, Rotter R, Schattner S, Mittlmeier T, Claes L, Vollmar B, Gradl G. Introduction of a new interlocked intramedullary nailing device for stabilization of critical size femoral defects in the rat: A combined biomechanical and clinical study. J Orthop Res 26:184-189, 2008

Siebert N, Cantré D, Eipel C, Vollmar B. H2S contributes to the hepatic arterial buffer response and mediates vasorelaxation of the hepatic artery via activation of KATP channels. Am J Physiol Gastrointest Liver Physiol 295:G1266-1273, 2008

Sorg H, Lorch B, Jaster R, Fitzner B, Ibrahim S, Holzhueter SA, Nizze H, Vollmar B. Early rise in inflammation and microcirculatory disorder determine the development of autoimmune pancreatitis in the MRL/Mp-mouse. Am J Physiol Gastrointest Liver Physiol 295:G1274-1280, 2008

Szabo A, Vollmar B, Boros M, Menger MD. In vivo fluorescence microscopic imaging for dynamic quantitative assessment of intestinal mucosa permeability in mice. J Surg Res 145:179-185, 2008

Vollmar B, Franke K, Menger MD. Nutritive perfusion of pancreatic endocrine tissue during hemorrhagic hypotension: how differ islets in situ from islet isografts? Shock 30:428-433, 2008

 

Übersichtsartikel, Buchbeiträge, Editorials, Briefe und Kommentare

Harder Y, Amon M, Laschke MW, Schramm R, Rücker M, Wettstein R, Bastiaanse J, Frick A, Machens HG, Küntscher M, Germann G, Vollmar B, Erni D, Menger MD. An old dream revitalised: preconditioning strategies to protect surgical flaps from critical ischaemia and ischaemia-reperfusion injury. J Plast Reconstr Aesthet Surg 61:503-511, 2008

2007

Peer-review Originalarbeiten

Abshagen K, Eipel C, Menger MD, Kalff JC, Vollmar B. Loss of NF-kappaB activation in Kupffer cell-depleted mice impairs liver regeneration after partial hepatectomy. Am J Physiol Gastrointest Liver Physiol 292:G1570-1577, 2007

Eipel C, Eisold M, Schuett H, Vollmar B. Inhibition of heme oxygenase-1 protects against tissue injury in carbon tetrachloride exposed livers. J Surg Res 139:113-120, 2007

Eipel C, Hirschmann M, Abshagen K, Menger MD, Vollmar B. Local interaction of apoptotic hepatocytes and Kupffer cells in a rat model of systemic endotoxemia. Hepatol Res 37:863-871, 2007

Eipel C, Kidess E, Abshagen K, LeMinh K, Menger MD, Burkhardt H, Vollmar B. Antileukoproteinase protects against NFkappa B-dependent inflammatory liver injury, but fails to block apoptosis-driven lethality in the response of D-galactosaminesensitized mice to lipopolysaccharide. Br J Pharmacol 151:406- 413, 2007

Gierer P, Hoffmann JN, Mahr F, Menger MD, Mittlmeier T, Gradl G, Vollmar B. Activated protein C reduces tissue hypoxia, inflammation, and apoptosis in traumatized skeletal muscle during endotoxemia. Crit Care Med 35:1966-1971, 2007

Gradl G, Finke B, Schattner S, Gierer P, Mittlmeier T, Vollmar B. Continuous intra-arterial application of substance P induces signs and symptoms of experimental CRPS such as edema, inflammation and mechanical pain but no thermal pain. Neuroscience 148:757-765, 2007

Kollmar O, Corsten M, Scheuer C, Vollmar B, Schilling M, Menger MD. Portal branch ligation induces a hepatic arterial buffer response, microvascular remodeling and cell proliferation in portal blood-deprived liver tissue. Am J Physiol Gastrointest Liver Physiol 292:G1534-1542, 2007

Laschke MW, Elitzsch A, Scheuer C, Vollmar B, Menger MD. Selective cyclooxygenase-2 inhibition induces regression of autologous endometrial grafts by down-regulation of vascular endothelial growth factor-mediated angiogenesis and stimulation of caspase-3-dependent apoptosis. Fertil Steril 87:163-171, 2007

Le-Minh K, Klemm K, Abshagen K, Eipel C, Menger MD, Vollmar B. Attenuation of inflammation and apoptosis by pre- and post-treatment of darbepoetin alpha in acute liver failure of mice. Am J Pathol 170:1954-1963, 2007

Lindenblatt N, Menger MD, Klar E, Vollmar B. Darbepoetinalpha does not promote microvascular thrombus formation in mice: role of eNOS-dependent protection through platelet and endothelial cell deactivation. Arterioscler Thromb Vasc Biol 27:1191-1198, 2007

Lindenblatt N, Platz U, Hameister J, Klar E, Menger MD, Vollmar B. Distinct effects of acute and chronic nicotine application on microvascular thrombus formation and endothelial function in male and female mice. Langenbecks Arch Surg 392:285-295, 2007

Menger MD, Vollmar B. Pathomechanisms of ischemia-reperfusion injury as the basis for novel preventive strategies: is it time for the introduction of pleiotropic compounds? Transplant Proc 39:485-488, 2007

Schoen M, Rotter R, Gierer P, Gradl G, Strauss U, Jonas L, Mittlmeier T, Vollmar B. Ischemic preconditioning prevents skeletal muscle tissue injury, but not nerve lesion upon tourniquetinduced ischemia. J Trauma 63:788-797, 2007

Schuett H, Eipel C, Maletzki C, Menger MD, Vollmar B. NO counterbalances HO 1 overexpression-induced acceleration of hepatocyte proliferation in mice. Lab Invest 87:606-612, 2007

Sorg H, Hoffmann JN, Rumbaut RE, Menger MD, Bellera RV, Lindenblatt N, Vollmar B. Efficacy of antithrombin in the prevention of microvascular thrombosis during endotoxemia: an intravital microscopic study. Thromb Res 121:241-248, 2007

Sorg H, Krueger C, Vollmar B. Extending the scope out of the chamber: Intravital insights in skin wound healing. J Anat 211:810-818, 2007

Stratos I, Rotter R, Eipel C, Mittlmeier T, Vollmar B. Granulocyte- colony stimulating factor (G-CSF) enhances muscle proliferation and strength following skeletal muscle injury in rats. J Appl Physiol 103:1857-1863, 2007

Zhivov A, Stave J, Vollmar B, Guthoff R. In vivo confocal microscopic evaluation of Langerhans cell density and distribution in the corneal epithelium of healthy volunteers and contact lens wearers. Cornea 26:47-54, 2007

Schmidt A, Kuhla B, Bigl K, Münch G, Arendt T. Cell cycle related signaling in Neuro2a cells proceeds via the receptor for advanced glycation end products. J Neural Transm 114:1413-1424, 2007

Kuhla B, Boeck K, Schmidt A, Ogunlade V, Arendt T, Münch G, Lüth HJ. Age- and stage-dependent glyoxalase I expression and its activity in normal and Alzheimer's disease brains. Neurobiol Aging 28:29-41, 2007

 

Übersichtsartikel, Buchbeiträge, Editorials, Briefe und Kommentare

Menger MD, Vollmar B. Pathomechanisms of ischemia-reperfusion injury as the basis for novel preventive strategies: is it time for the introduction of pleiotropic compounds? Transplant Proc 39:485-488, 2007

2006

Peer-review Originalarbeiten

Laschke MW, Elitzsch A, Vollmar B, Vajkoczy P, Menger MD. Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions. Hum Reprod 21:262-268, 2006

Lindenblatt N, Braun B, Menger MD, Klar E, Vollmar B. C-peptide exerts antithrombotic effects that are repressed by insulin in normal and diabetic mice. Diabetologia 49:792-800, 2006

Szabo A, Vollmar B, Boros M, Menger MD. Gender differences in ischemia-reperfusion-induced microcirculatory and epithelial dysfunctions in the small intestine. Life Sci 78:3058-3065, 2006

Slotta JE, Scheuer C, Menger MD, Vollmar B. Immunostimulatory CpG-oligodeoxynucleotides (CpG-ODN) induce early hepatic injury, but provide a late window for protection against endotoxin-mediated liver damage. J Hepatol 44:576-585, 2006

Bordel R, Laschke MW, Menger MD, Vollmar B. Nicotine does not affect vascularization but inhibits growth of freely transplanted ovarian follicles by inducing granulosa cell apoptosis. Hum Reprod 21:610-617, 2006

Szabo A, Vollmar B, Boros M, Menger MD. Gender differences in ischemia-reperfusion-induced microcirculatory and epithelial dysfunctions in the small intestine. Life Sci 78:3058-3065, 2006

Amon M, Laschke MW, Harder Y, Vollmar B, Menger MD. Impact of severity of local soft-tissue trauma on long-term manifestation of microcirculatory and microlymphatic dysfunctions. J Trauma 61:924-932, 2006

Abshagen K, Eipel C, Menger MD, Vollmar B. Comprehensive analysis of the regenerating mouse liver: an in vivo fluorescence microscopic and immunohistological study. J Surg Res 134:354-362, 2006

Roesner JP, Vagts DA, Iber T, Eipel C, Vollmar B, Nöldge-Schomburg GFE. Protective effects of poly-(ADP-ribose)-polymerase inhibition on rat liver microcirculation and function after haemorrhagic shock and resuscitation. Intensive Care Med 32:1649-1657, 2006

Rucker M, Schafer T, Scheuer C, Harder Y, Vollmar B, Menger MD. Local heat shock priming promotes recanalization of thromboembolized microvasculature by upregulation of plasminogen activators. Arterioscler Thromb Vasc Biol 26:1632-1639, 2006

Gradl G, Gaida S, Finke B, Gierer P, Mittlmeier T, Vollmar B. Exaggeration of tissue trauma induces signs and symptoms of acute CRPS I, however displays distinct differences to experimental CRPS II. Neurosci Lett 402:267-272, 2006

Laschke MW, Elitzsch A, Scheuer C, Holstein JH, Vollmar B, Menger MD. Rapamycin induces regression of endometriotic lesions by inhibiting neovascularization and cell proliferation. Br J Pharmacol 149:137-144, 2006

Sehnert B, Gierer P, Ibrahim S, Kühl A, Cavcic A, Voll R, Nanakumar KS, Holmdahl R, Hallmann, Vollmar B, Burkhardt H. Modulation of granulocyte-endothelial interactions by antileukoproteinase: inhibition of anti-type II collagen antibody-induced leukocyte-attachment to the synovial endothelium. Arthritis Res Ther 8:R95, 2006

Sorg H, Hoffmann JN, Menger MD, Lindenblatt N, Goehring P, Vollmar B. Antithrombin is as effective as heparin and hirudin to prevent formation of microvascular thrombosis in a murine model. Thromb Haemost 96:371-377, 2006

Lindenblatt N, Menger MD, Klar E, Vollmar B. Systemic hypothermia increases PAI-1 expression and accelerates microvascular thrombus formation in endotoxemic mice. Crit Care 10:R148, 2006

Kuhla B, Boeck K, Lüth HJ, Schmidt A, Weigle B, Schmitz M, Ogunlade V, Münch G, Arendt T. Age-dependent changes of glyoxalase I expression in human brain. Neurobiol Aging 27:815-822, 2006.

 

Übersichtsartikel, Buchbeiträge, Editorials, Briefe und Kommentare

Laschke MW, Harder Y, Amon M, Martin I, Farhadi J, Ring A, Torio-Padron N, Schramm R, Rucker M, Junker D, Haufel JM, Carvalho C, Heberer M, Germann G, Vollmar B, Menger MD. Angiogenesis in tissue engineering: breathing life into constructed tissue substitutes. Tissue Eng 12:2093-2104, 2006

Vollmar B, Eipel C, Menger MD. Organdysfunktion und gestörte Mikrozirkulation des septischen Patienten. Viszeralchirurgie 41:11-17, 2006

Hoffmann JN, Fertmann JM, Schick K, Mauer M, Wirschung KC, Vollmar B, Menger MD, Jauch KW. Organversagen Mikrozirkulation: Diagnostik und therapeutische Konsequenzen. Dtsch Med Wochenschr 131:31-34, 2006

Menger MD, Vollmar B. Perspektiven in der Schockforschung. Notfall Rettungsmed 9:542-546, 2006

Menger MD, Laschke MW, Vollmar B. Chamber Assays. In: Staton CA, Lewis C, Bicknell R (eds.). Angiogenesis assays: a critical appraisal of current techniques. John Wiley & Sons Ltd, West Sussex, Uk, pp 239-263, 2006

2005

Peer-review Originalarbeiten

Richter S, Pistorius G, Seidel R, Feifel G, Schilling MK, Vollmar B, Menger MD. Arteriolo-venular shunting critically determines shutdown of microcirculation upon cryotherapy in tumor-bearing rat liver. Ann Surg Oncol 12:303-312, 2005

Rucker M, Kadirogullari B, Vollmar B, Spitzer WJ, Menger MD. Improvement of nutritive perfusion after free tissue transfer by local heat shock-priming-induced preservation of capillary flowmotion. J Surg Res 123:102-108, 2005

Eipel C, Glanemann M, Nüssler AK, Menger MD, Neuhaus P, Vollmar B. Ischemic preconditioning impairs liver regeneration in extended reduzed-size livers. Ann Surg 241:477-484, 2005

Glawe C, Emmrich J, Sparmann G, Vollmar B. In vivo characterization of developing chronic pancreatitis in rats. Lab Invest 85:193-204, 2005

Schaser KD, Puhl G, Vollmar B, Menger MD, Stover JF, Kohler K, Neuhaus P, Settmacher U. In vivo imaging of human pancreatic microcirculation and pancreatic tissue injury in clinical pancreas transplantation. Am J Transplant 5:341-350, 2005

Gierer P, Mittlmeier T, Bordel R, Schaser KD, Gradl G, Vollmar B. Selective cyclooxygenase-2 inhibition reverses microcirculatory and inflammatory sequelae of closed soft-tissue trauma in an animal model. J Bone Joint Surg Am 87-A(1):153-160, 2005

Cui YF, Ma M, Wang GY, Han DE, Vollmar B, Menger MD. Prevention of core cell damage in isolated islets of Langerhans by low temperature preconditioning. World J Gastroenterol 11:545-550, 2005

Nakamura T, Abu-Dahab R, Menger MD, Schäfer U, Vollmar B, Wada H, Lehr CM, Schäfers HJ. Depletion of alveolar macrophages by clodronate-liposomes aggravates ischemia-reperfusion injury of the lung. J Heart Lung Transplant 24:38-45, 2005

Bordel R, Laschke M, Menger MD, Vollmar B. Inhibition of p53 during physiological angiogenesis in the hamster ovary does not affect extent of new vessel fromation but delays vessel maturation. Cell Tiss Res 320:427-435, 2005

Zhivov A, Stave J, Vollmar B, Guthoff R. In vivo confocal microscopic evaluation of Langerhans cell density and distribution in the normal human corneal epithelium. Graefes Arch Clin Exp Opthalmol 243:1056-1061, 2005

Gierer P, Ibrahim S, Mittlmeier T, Koczan D, Landes J, Gradl G, Vollmar B. Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis. Arthritis Res Ther 7:R868-876, 2005

Knappe T, Mittlmeier T, Eipel C, Amon M, Menger MD, Vollmar B. Effect of systemic hypothermia on local soft tissue trauma-induced microcirculatory and cellular dysfunction in mice. Crit Care Med 33:1805-1813, 2005

Puhl G, Schaser KD, Pust D, Kohler K, Vollmar B, Menger MD, Neuhaus P, Settmacher U. Initial hepatic microcirculation correlates with early graft function in human orthotopic liver transplantation. Liver Transpl 11:555-563, 2005

Eipel C, Schuett H, Bordel R, Menger MD, Vollmar B. Pifithrin-alpha induced p53 inhibition does not affect liver regeneration after partial hepatectomy in mice. J Hepatol 43:829-835, 2005

Gradl G, Gaida S, Finke B, Lindenblatt N, Gierer P, Menger MD, Mittlmeier T, Vollmar B. Supernatant of traumatized muscle induces inflammation and pain, but not microcirculatory perfusion failure and apoptotic cell death. Shock 24:219-225, 2005

Laschke MW, Elitzsch A, Vollmar B, Menger MD. In vivo analysis of angiogenesis in endometriosis-like lesions by intravital fluorescence microscopy. Fertil Steril 84:1199-1209, 2005

Lindenblatt N, Menger MD, Klar E, Vollmar B. Sustained hypothermia accelerates microvascular thrombus formation in mice. Am J Physiol Heart Circ Physiol 289:H2680-H2687, 2005

Glanemann M, Eipel C, Nussler AK, Vollmar B, Neuhaus P. Hyperperfusion syndrome in small-for-size livers. Eur Surg Res 37:335-341, 2005

 

Übersichtsartikel, Buchbeiträge, Editorials, Briefe und Kommentare

Menger MD, Vollmar B. Kupffer cell ablation improves hepatic microcirculation after trauma and sepsis. J Trauma 59:784, 2005

Menger MD, Vollmar B. Rat model of femur fracture and cecal ligation and puncture. J Trauma 9:784, 2005

Hoffmann JN, Vollmar B, Laschke MW, Fertmann JM, Jauch KW, Menger MD. Microcirculatory alterations in ischemia-reperfusion injury and sepsis: effects of activated protein C and thrombin inhibition. Crit Care 9(suppl 4):S33-S37, 2005

Menger MD, Vollmar B. Microvascular responses to organ transplantation. In: Preedy VR, Peters TJ (eds). Skeletal muscle: Pathology, diagnosis and management of disease. Elsevier Science, USA, pp 843-848, 2005

2004

Peer-review Originalarbeiten

Leister I, Schuler P, Vollmar B, Fuzesi L, Kahler E, Becker H, Markus PM. Microcirculation and excretory function of the liver under conditions of carbon dioxide pneumoperitoneum. Surg Endosc 18:1358-1363, 2004

Gierer P, Vollmar B, Schaser KD, Andreas C, Gradl G, Mittlmeier T. Efficiency of small volume resuscitation in restoration of disturbed skeletal muscle microcirculation after soft tissue trauma and hemorrhagic shock. Langenbecks Arch Surg 389:40-45, 2004

Lindenblatt N, Bordel R, Schareck W, Menger MD, Vollmar B. Vascular heme oxygensae-1 induction suppresses microvascular thrombus formation in vivo. Arterioscler Thromb Vasc Biol 24:601-606, 2004

Eipel C, Bordel R, Nickels RM, Menger MD, Vollmar B. Impact of leukocytes and platelets in mediating hepatocyte apoptosis in a rat model of systemic endotoxemia. Am J Physiol Gastrointest Liver Physiol 286:G769-G776, 2004

Hoffmann JN, Vollmar B, Laschke MW, Inthorn D, Fertmann J, Römisch J, Schildberg FW, Menger MD. Microhemodynamic and cellular mechanisms of activated protein C action during endotoxemia. Crit Care Med 32:1011-1017, 2004

Busch CJ, Wanner GA, Menger MD, Vollmar B. Granulocyte colony-stimulating factor (G-CSF) reduces not only gram-negative but also gram-positive infection-associated proinflammatory cytokine release by Kupffer cells via modulation of neutrophil function. Inflamm Res 2004 53:205-210, 2004

Laschke MW, Cengiz Z, Hoffmann JN, Roemisch J, Menger MD, Vollmar B. Latent antithrombin does not affect physiological angiogenesis: an in vivo study on vascularization of grafted follicles. Life Sci 75:203-213, 2004

Puhl G, Schaser KD, Pust D, Köhler K, Vollmar B, Menger MD, Neuhaus P, Settmacher U.The delay of rearterialization after initial portal reperfusion in living donor liver transplantation significantly determines the development of microvascular graft dysfunction. J Hepatol 41:299-306, 2004

Kaminski A, Backhaus C, Sponholz C, Stamm C, Vollmar B, Steinhoff G. Upregulation of endothelial nitric oxide synthase inhibits pulmonary leukocyte migration following lung ischemia/reperfusion in mice. Am J Pathol 164:2241-2249, 2004

Nakamura T, Vollmar B, Menger MD, Wada H, Inui K, Schäfers HJ. Heme oxygenase does not contribute to the control of basal vascular tone in isolated blood-perfused rat lung. J Heart Lung Transplant 23:599-605, 2004

El-Gibaly AM, Scheuer C, Menger MD, Vollmar B. Improvement of rat liver graft quality by pifithrin-alpha-mediated inhibition of hepatocellular apoptosis. Hepatology 39:1553-1562, 2004

Gradl G, Gaida S, Gierer P, Mittlmeier T, Vollmar B. In vivo evidence for apoptosis, but not inflammation in the hindlimb muscle of neuropathic rats. Pain 112:121-130, 2004

 

Dallmann K, Junker H, Balabanov S, Zimmermann U, Giebel J, Walther R. Human agmatinase is diminished in the clear cell type of renal cell carcinoma. Int J Cancer 108:342-347, 2004

 

Übersichtsartikel, Buchbeiträge, Editorials, Briefe und Kommentare

Vollmar B, Menger MD. Rolle der Mikrozirkulation und Leukozyten-Endothelzell-Interaktion. Transplant Linc 1:24-34, 2004

Menger MD, Vollmar B. Current concepts in clinical surgery: Surgical Trauma: Hyperinflammation versus immunosuppression? Langenbecks Arch Surg 389:475-484, 2004

Vollmar B, Menger MD. Current concepts in clinical surgery: Volume replacement and microhemodynamic changes in polytrauma. Langenbecks Arch Surg 389:485-491, 2004

Vollmar B, Menger MD. Was gibt es Neues in der Chirurgischen Forschung: Ischämie und Reperfusion. In: Meßmer K, Witte J, Jähne J, Neuhaus P (Hrsg). Was gibt es Neues in der Chirurgie. Ecomed Verlag, Landsberg, Kapitel I, pp 1-10, 2004

2003

Peer-review Originalarbeiten

Leister I, Schüler P, Vollmar B, Stojanovic T, Füzesi L, Becker H, Markus PM. A peritoneal cavity chamber for intravital microscopy of the liver under conditions of pneumoperitoneum. Surg Endosc 17:939-942, 2003

Vollmar B, Slotta J, Nickels RM, Wenzel E, Menger MD. Comparative analysis of platelet isolation techniques for the in vivo study of the microcirculation. Microcirculation 10:143-152, 2003

Mittlmeier T, Vollmar B, Menger MD, Schewior L, Schaser KD. Small volume hypertonic hydroxyethylstarch reduces acute microvascular dysfunction following closed soft tissue trauma. J Bone Joint Surg [Br] 85:126-132, 2003

Glanemann M, Vollmar B, Nussler AK, Schaefer T, Neuhaus P, Menger MD. Ischemic preconditioning protects from hepatic ischemia/reperfusion-injury by preservation of microcirculation and mitochondrial redox state. J Hepatol 38:59-66, 2003

Schramm R, Yamauchi J, Vollmar B, Vaikoczy P, Menger MD. Blockade of in vivo VEGF- KDR/flk-1 signaling does not affect revascularization of freely transplanted pancreatic islets. Transplantation 75:239-242, 2003

Schaser KD, Puhl G, Zhang L, Mittlmeier T, Stover J, Vollmar B, Menger MD, Neuhaus P, Haas N, Settmacher U. Non-invasive analysis of conjunctival microcirculation during carotid artery surgery reveals microvascular evidence of collateral compensation and stenosis-dependent adaptation. J Vasc Surg 37:789-797, 2003

Amon M, Menger MD, Vollmar B. Heme oxygenase and nitric oxide synthase mediate cooling-associated protection against TNF-a-induced microcirculatory dysfunction and apoptotic cell death. FASEB J 17:175-185, 2003

Hildebrandt U, Kessler K, Plusczyk T, Pistorius G, Vollmar B, Menger MD. Comparison of surgical stress between laparoscopic and open colonic resections. Surg Endosc 17:242-246, 2003

Yamauchi J, Schramm R, Richter S, Vollmar B, Menger MD, Minor T. Improvement of microvascular graft equilibration and preservation in non-heart-beating donors by warm preflush with streptokinase. Transplantation 75:449-453, 2003

Puhl G, Schaser KD, Vollmar B, Menger MD, Settmacher U. Non-invasive in vivo analysis of the human hepatic microcirculation using orthogonal polarization spectral (OPS)-imaging. Transplantation 75:756-761, 2003

Schäfer T, Scheuer C, Roemer K, Menger MD, Vollmar B. Inhibition of p53 protects liver tissue against endotoxin-induced apoptotic and necrotic cell death. FASEB J 17:660-667, 2003

Laschke MW, Menger MD, Vollmar B. Cryopreservation does not affect neovascularisation of freely transplanted ovarian follicles. Fertil Steril 79:1458-1460, 2003

Nickels RM, Seyfert UT, Wenzel E, Menger MD, Vollmar B. A simple and reproducible method to reliably assess platelet activation. Thromb Res 110:53-56, 2003

 

Huwer H, Winning J, Vollmar B, Welter C, Löhbach C, Menger MD, Schäfers HJ. Long-term cell survival and hemodynamic improvements after neonatal cardiomyocyte and satellite cell transplantation into healed myocardial cryoinfarcted lesions in rats. Cell Transplant 12:757-767, 2003

Kawashima M, Nakamura T, Schneider S, Vollmar B, Lausberg HF, Bauer M, Menger MD, Schäfers HJ. Iloprost ameliorates postischemic lung reperfusion injury and maintains an appropriate pulmonary ET-1 balance. J Heart Lung Transplant 22:794-801, 2003

Lindenblatt N, Schareck W, Belusa L, Nickels RM, Menger MD, Vollmar B. Anti-oxidant ebselen delays microvascular thrombus formation in the rat cremaster muscle by inhibiting platelet P-selectin expression. Thromb Haemost 90:882-892, 2003

Rucker M, Strobel O, Vollmar B, Spitzer WJ, Menger MD. Protective skeletal muscle arteriolar vasomotion during critical perfusion conditions of osteomyocutaneous flaps is not mediated by nitric oxide and endothelins. Langenbecks Arch Surg 388:339-343, 2003

 

Übersichtsartikel, Buchbeiträge, Editorials, Briefe und Kommentare

Vollmar B, Menger MD. Microcirculatory dysfunction in acute pancreatitis. A new concept of pathogenesis involving vasomotion-associated arteriolar constriction and dilation. Pancreatology 3:181-190, 2003

Menger MD, Szabo A, Vollmar B. Microcirculatory dysfunction in intestinal ischemia-reperfusion. Arch Hellenic Med 20 (suppl A):33-38, 2003

Menger MD, Laschke M, Amon M, Schramm R, Thorlacius H, Rücker M, Vollmar B. Experimental models to study microcirculatory dysfunction in muscle ischemia-reperfusion and osteomyocutaneous flap transfer. Langenbecks Arch Surg 388:281-290, 2003

Berrevoet F, Schafer T, Vollmar B, Menger MD. Ischemic preconditioning: evidence to support clinical application in liver surgery and transplantation? Acta Chir Belg 103:485-489, 2003

2002

Peer-review Originalarbeiten

Laschke MW, Menger MD, Vollmar B. Ovariectomy improves neovascularization and microcirculation of freely transplanted ovarian follicles. J Endocrinol 172:535-544, 2002

Hoffmann JN, Vollmar B, Inthorn D, Schildberg FW, Menger MD. Antithrombin effects on endotoxin-induced microcirculatory disorders are mainly mediated by its interaction with microvascular endothelium. Crit Care Med 30:218-225, 2002

Vollmar B, Bauer C, Menger MD. n-3 polyunsaturated fatty acid-enriched diet does not protect from liver injury, but attenuates mortality rate in a rat model of systemic endotoxemia. Crit Care Med 30:1091-1098, 2002

Rücker M, Vollmar B, Roesken F, Spitzer WJ, Menger MD. Microvascular transfer-related abrogation of capillary flowmotion in critically reperfused composite flaps. Br J Plast Surg 55:129-135, 2002

Hoffmann JN, Vollmar B, Laschke MW, Inthorn D, Schildberg FW, Menger MD. Hydroxyethylstarch (130 kD), but not crystalloid volume support, improves microcirculation during normotensive endotoxemia. Anesthesiology 97:460-470, 2002

Vollmar B, Pradarutti S, Nickels RM, Menger MD. Age-associated loss of immunomodulatory protection by granulocyte-colony stimulating factor in endotoxic rats. Shock 18:348-354, 2002

Vollmar B, Heckmann C, Richter S, Menger MD. High, but not low, dietary retinoids aggravate manifestation of rat liver fibrosis. J Gastroenterol Hepatol 17:791-799, 2002

Vollmar B, Pradarutti S, Richter S, Menger MD. In vivo quantification of aging changes in the rat liver from early juvenile to senescent life. Liver 22:330-341, 2002

Hoffmann JN, Vollmar B, Laschke MW, Inthorn D, Kaneider NC, Dunzendorfer S, Wiedermann CJ, Roemisch J, Schildberg FW, Menger MD. Adverse effects of heparin on antithrombin action during endotoxemia: microhemodynamic and cellular mechanisms. Thromb Haemost 8:242-252, 2002

Vollmar B, El-Gibaly AM, Scheuer C, Strik MW, Bruch HP, Menger MD. Acceleration of cutaneous wound healing by transient p53-inhibition. Lab Invest 82:1063-1071, 2002

Schramm R, Scheuer C, Yamauchi J, Vollmar B, Menger MD. Heat shock preconditioning impairs revascularization of freely transplanted pancreatic islets. Transplantation 74:1544-1550, 2002

Rücker M, Schäfer T, Stamm A, Saueressig K, Vollmar B, Spitzer WJ, Menger MD. New model for quantitative in vivo assessment of embolization, thrombus formation and recanalization in the microcirculation of osteomyocutaneous flaps. J Surg Res 108:129-137, 2002

 

Übersichtsartikel, Buchbeiträge, Editorials, Briefe und Kommentare

Menger MD, Vollmar B. Die Bedeutung der Mikrozirkulationsstörung für die Manifestation des postischämischen Leberschadens. Chir Gastroenterol 18 (suppl 1):46-51, 2002

Menger MD, Laschke MW, Vollmar B. Viewing the microcirculation through the window: some twenty years experience with the hamster dorsal skinfold chamber. Eur Surg Res 34:83-91, 2002

Menger MD, Vollmar B. Capillary no-flow. In: Preedy VR, Peters TJ (eds). Skeletal muscle: Pathology, diagnosis and management of disease. Greenwich Medical Media Limited, London, San Francisco, pp 283-292, 2002